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Nicole Hazen, wife of Arizona Diamondbacks general manager Mike Hazen, died of complications from glioblastoma, a type of brain cancer. She is 45 years old.

She was diagnosed with cancer more than two years ago. The family has four sons, Charlie, John, Teddy and Sam. The team released a statement confirming that Hazen passed away on Thursday.

Red Sox Hazen Baseball
Mike Hesson poses with his wife Nicole and four sons at Fenway Park in Boston on Thursday, September 24, 2015. From left are sons Charlie, Sam, Teddy and John.

Charles Krupa/The Associated Press

“Nicole lived her life and loved her family with ferocity and dedication,” the Hassons said in a statement. “As a mother, wife and educator, she serves others and advocates for kindness every day. We are forever grateful for the love, support and acts of kindness that our family has shown us over the past two years and four months. . . if not With the help and generosity of our community, we could not have been on this path with her.”

Mike Hazen announced last year that he would be taking part of his leave to help care for his wife and family.

Glioblastoma is a cancer that occurs in the brain and spinal cord, according to Mayo Clinic.

The cancer afflicted the late Senators John McCain and Edward Kennedy, as well as Beau Biden, the late son of President Joe Biden.

In most cases, the exact underlying cause of glioblastoma is unknown, but in some cases it is associated with genetic syndromes: neurofibromatosis type 1, Turcot syndrome, and Li Fraumeni syndrome, According to the National Institutes of Health.

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